Decreased aortic glutathione levels may contribute to impaired nitric oxide-induced relaxation in hypercholesterolaemia
نویسندگان
چکیده
منابع مشابه
Decreased serum level of lipoxin A4 (LXA4) may contribute to the pathogenesis of allergic rhinitis
Background: Rhinitis is a prevalent chronic inflammatory disease of the nasal mucosa. Arachidonic acid-derived lipoxin A4 (LXA4) has long been recognized to exert crucial anti-inflammatory and pro-resolving effects on inflammatory responses through a specific receptor named formyl peptide receptor-2 (FPR2). This study aimed to determine the serum level of LXA4 as well as the relative mRNA expre...
متن کاملDecreased Exhaled Nitric Oxide Levels in Patients with Mitochondrial Disorders
BACKGROUND Nitric oxide (NO) deficiency may occur in mitochondrial disorders (MD) and can contribute to the pathogenesis of the disease. It is difficult and invasive to measure systemic nitric oxide. NO is formed in the lungs and can be detected in expired air. Currently, hand-held fractional exhaled nitric oxide (FeNO) measurement devices are available enabling a fast in-office analysis of thi...
متن کاملDecreased sensitivity to vasoconstrictors in aortic rings after acute exposure to nitric oxide.
Nitric oxide (NO) has been postulated as a regulator of vascular reactivity, and the current study tested the hypothesis that NO-induced decreased sensitivity to vasoconstrictors persists following removal of NO. Endothelium-denuded segments of rat aorta were incubated 2-4 h at 37 degrees C with the NO donor S-nitroso-N-acetylpenicillamine (SNAP). Incubation produced rightward shifts in concent...
متن کاملInvolvement of mitochondrial peroxynitrite in nitric oxide-induced glutathione synthesis.
Cells respond to oxidative stress including nitric oxide (NO) by increasing cellular glutathione concentration, as a part of adaptive response against oxidative injury. To elucidate the mechanism by which NO induces glutathione we investigated the reactive oxygen species (ROS) generated in the cell. Treatment of RAW264.7 cells with NO donor, sodium nitroprusside (SNP), resulted in a temporary i...
متن کاملAortic connexin43 is decreased during hypertension induced by inhibition of nitric oxide synthase.
Connexin43 (Cx43), the predominant gap junction protein in vessels and heart, is involved in the control of cell-to-cell communication and is thought to modulate the contractility of the vascular wall and the electrical coupling of cardiac myocytes. We have investigated the effects of arterial hypertension induced by inhibition of nitric oxide synthase on the expression of Cx43 in aorta and hea...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 2000
ISSN: 0007-1188
DOI: 10.1038/sj.bjp.0703127